MOTS-C – Research Compound

MOTS-C — Research Compound

MOTS-C is a mitochondrial-derived peptide encoded within the mitochondrial DNA, known for its significant role in regulating metabolic homeostasis. It primarily interacts with the folate cycle and the AMPK signalling pathway, influencing how cells utilise glucose and fatty acids. Researchers study MOTS-C to investigate its ability to mimic the effects of exercise at a cellular level and its potential to reverse age-related metabolic decline and insulin resistance.

Findings from early-stage clinical trials have reported:

• Enhanced glucose clearance and improved insulin sensitivity observed in experimental models
• Reductions in fat mass and the prevention of high-fat diet-induced obesity reported in-vivo
• Increased levels of endogenous AICAR and activation of the AMPK pathway noted in cellular studies
• Improvements in physical performance and treadmill running capacity observed in ageing research subjects

Researchers study MOTS-C to understand the communication between mitochondria and the nuclear genome. By focusing on its role as a “mitokine,” it serves as a valuable tool for investigating longevity and the prevention of metabolic dysfunction. Its unique mitochondrial origin makes it a focal point for research into how cellular energy production influences systemic health and physical endurance.

Available Formats:
This compound is available as a vial of lyophilised powder, or can be ordered in a disposable pen, a reusable pen, or a cartridge for an existing reusable pen system.

Used solely for in vitro experiments and cannot be:

• Used in clinical trials involving humans
• Administered to humans as part of an experiment or investigation
• Supplied to another party for human investigational use