IGF-1 LR3 (1mg) — Research Compound
IGF-1 LR3 (Long Arginine 3-IGF-1) is a synthetic analogue of human Insulin-like Growth Factor-1 (IGF-1), modified to include an additional 13 amino acids and a substitution at the third position. This modification significantly reduces its binding to IGF-binding proteins (IGFBPs), resulting in a much longer half-life and higher biological potency. Researchers study IGF-1 LR3 for its role in cellular proliferation, muscle hypertrophy, and its ability to stimulate the transport of amino acids and glucose into muscle cells.
Findings from early-stage clinical trials have reported:
- Marked increases in muscle cell hyperplasia (the growth of new muscle cells) observed in research models
- Significant improvements in nitrogen retention and protein synthesis rates reported in-vivo
- Enhanced glucose uptake and improved nutrient partitioning noted across experimental cohorts
- Sustained elevations in systemic anabolic activity observed due to reduced protein binding
Researchers study IGF-1 LR3 to investigate the limits of myogenic development and the regulation of cellular growth pathways. Its extended half-life allows for the study of continuous IGF-1 receptor activation, making it a specialized tool for understanding muscle wasting, tissue regeneration, and the biological response to chronic anabolic signaling. It is a primary focus for research into the preservation of lean mass and the recovery of skeletal muscle function.
Available Formats:
This compound is available as a vial of lyophilised powder, or can be ordered in a disposable pen, a reusable pen, or a cartridge for an existing reusable pen system.
Used solely for in vitro experiments and cannot be:
- Used in clinical trials involving humans
- Administered to humans as part of an experiment or investigation
- Supplied to another party for human investigational use
| IDENTIFICATION | |
| Product Name | IGF-1 LR3 1 mg |
| Catalogue Number | RP-IGF1LR3-01 |
| CAS Number | 946870-92-4 |
| Molecular Weight (g/mol) | ~9111 g/mol |
| Molecular Formula | C990H1528N264O300S7 |
| Peptide Sequence | Modified IGF-1 analogue (LR3) |
| PHYSICAL AND CHEMICAL PROPERTIES | |
| Active Ingredient | IGF-1 LR3 |
| Appearance | White to off-white lyophilised powder |
| Melting Point | Not applicable (decomposes before melting) |
| ANALYTICAL AND QUALITY CONTROL | |
| Mass Spectrum | Conforms to specification |
| Structural Confirmation | Consistent with theoretical structure / sequence |
| RESEARCH USE AND SAFETY | |
| Caution | Handle using appropriate PPE and in compliance with relevant laboratory safety standards. |
| Intended Use | For laboratory research use only. Not for human or veterinary use. |
| Hazard Classification | Not classified as hazardous under GHS for research quantities |
| STORAGE, HANDLING AND STABILITY | |
| Storage Temperature, Opened | -20 °C, minimise freeze–thaw cycles |
| Storage Temperature, Unopened | -20 °C recommended for long-term storage |
| Shelf Life | 2 years unopened under recommended conditions |
| Reconstitution Stability | Stable for up to 28 days at 2–8 °C in aqueous solution under sterile conditions |


