MT-1 (Melanotan-1) 10 mg – Research Compound
MT1, or Afamelanotide, is a synthetic analogue of the naturally occurring peptide alpha-melanocyte-stimulating hormone (α-MSH). It is a non-selective agonist of the melanocortin receptors, primarily targeting MC1R on skin cells. Researchers study MT1 for its ability to stimulate melanogenesis (the production of melanin) independently of ultraviolet (UV) radiation. It is investigated as a photoprotective agent, with studies focusing on its ability to increase skin pigmentation and reduce DNA damage caused by solar exposure.
Findings from early-stage clinical trials have reported:
- Significant increases in skin melanin density and pigmentation observed in research subjects
- Reductions in the severity of skin damage and solar urticaria reported in experimental models
- Protective effects against UV-induced oxidative stress and DNA damage noted in-vitro
- Improved skin tolerance to light exposure reported across multiple clinical study groups
Researchers study MT1 to explore the mechanisms of biological photoprotection and the prevention of UV-linked dermal pathologies. By analyzing the activation of the MC1R pathway, it serves as a specialized tool for understanding the body’s innate defense against radiation. This makes it an essential compound for research into erythropoietic protoporphyria (EPP), skin cancer prevention, and the regulation of pigmentation markers.
Available Formats:
This compound is available in a 9ml premixed spray bottle, providing a stable solution for precise administration in research settings.
Used solely for in vitro experiments and cannot be:
- Used in clinical trials involving humans
- Administered to humans as part of an experiment or investigation
- Supplied to another party for human investigational use
| IDENTIFICATION | |
| Product Name | MT-1 (Afamelanotide) 10 mg |
| Catalogue Number | RP-MT1-01 |
| CAS Number | 75921-69-6 |
| Molecular Weight (g/mol) | 1646.9 g/mol |
| Molecular Formula | C78H111N21O19 |
| Peptide Sequence | Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| PHYSICAL AND CHEMICAL PROPERTIES | |
| Active Ingredient | MT-1 (Afamelanotide) |
| Appearance | White to off-white lyophilised powder |
| Melting Point | Not applicable (decomposes before melting) |
| ANALYTICAL AND QUALITY CONTROL | |
| Mass Spectrum | Conforms to specification |
| Structural Confirmation | Consistent with theoretical structure / sequence |
| RESEARCH USE AND SAFETY | |
| Caution | Handle using appropriate PPE and in compliance with relevant laboratory safety standards. |
| Intended Use | For laboratory research use only. Not for human or veterinary use. |
| Hazard Classification | Not classified as hazardous under GHS for research quantities |
| STORAGE, HANDLING AND STABILITY | |
| Storage Temperature, Opened | -20 °C, minimise freeze–thaw cycles |
| Storage Temperature, Unopened | -20 °C recommended for long-term storage |
| Shelf Life | 2 years unopened under recommended conditions |
| Reconstitution Stability | Stable for up to 28 days at 2–8 °C in aqueous solution under sterile conditions |
Certificate of Analysis – MT1 (99% Purity Verified)
| COMPOUND IDENTIFICATION | |
| Product Name | Melanotan I (MT1) 10mg Spray |
| Batch / Reference ID | MT101218 |
| Sample Form | White powder in glass vial |
| ANALYTICAL RESULTS | |
| Chemical Purity | 99% (Verified) |
| Measured Content | 10.53 mg (± 0.05 mg) |
| Test Method | HPLC (High-Performance Liquid Chromatography) |
| LABORATORY TESTING INFORMATION | |
| Analysis Period | 03 Mar 2026 – 09 Mar 2026 |
| Laboratory Order # | 100012943 |
| QUALITY ASSURANCE | |
| Quality Testing Standards | All River Peptides products undergo batch-level laboratory analysis to verify compound identity and confirm purity levels. Learn more on our Quality Testing & Purity Verification page. |


