5-Amino-1MQ 10mg

5-Amino-1MQ (10mg) — Research Compound

5-Amino-1MQ is a small molecule that functions as a selective, membrane-permeable inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). This enzyme plays a critical role in cellular energy metabolism by regulating the levels of nicotinamide adenine dinucleotide (NAD+). In research settings, 5-Amino-1MQ is studied for its ability to prevent the depletion of NAD+ and its consequent impact on metabolic efficiency and muscle cell regeneration.

Findings from early-stage clinical trials have reported:

• Reductions in white adipose tissue mass of approximately 30% observed in experimental rodent models
  
• Increases in intracellular NAD+ levels and ATP production reported in muscle cell cultures
  
• Improved contractile force and enhanced recovery of injured muscle fibres noted in-vivo
  
• Alterations in the expression of genes associated with lipid metabolism observed in research studies
  

Researchers study 5-Amino-1MQ to better understand the role of the NNMT pathway in metabolic disorders and muscle wasting. Its ability to influence cellular energy homeostasis without affecting systemic neurotransmitter levels makes it a unique tool for investigating metabolic health at the cellular level. This compound is essential for research into the biological mechanisms of ageing and the potential for pharmacological intervention in energy-intensive tissues.

Available Formats:
This compound is available as a vial of lyophilised powder, or can be ordered in a disposable pen, a reusable pen, or a cartridge for an existing reusable pen system.

Used solely for in vitro experiments and cannot be:

• Used in clinical trials involving humans
• Administered to humans as part of an experiment or investigation
• Supplied to another party for human investigational use

References

• NAD+ restoration and metabolic pathway research involving NNMT inhibition
  Northumbria researchers reviewed pathways connected with nicotinamide metabolism and highlighted the growing interest in NNMT inhibition for metabolic regulation and NAD+ preservation. This publication provides strong UK-based academic context relevant to 5-Amino-1MQ research. https://researchportal.northumbria.ac.uk/ws/portalfiles/portal/65959909/1_s2.0_S0006295222000405_main.pdf
• Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice
  This foundational study examined selective NNMT inhibition using 5-Amino-1MQ and reported measurable reductions in adipose tissue with associated metabolic pathway effects in preclinical models. https://pmc.ncbi.nlm.nih.gov/articles/PMC5826726/
• Reduced calorie diet combined with NNMT inhibition using 5-Amino-1MQ
  A follow-up metabolic study exploring NNMT inhibition and diet intervention. Researchers observed notable changes in adiposity and metabolic outcomes in experimental models. https://www.nature.com/articles/s41598-021-03670-5
• Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes
  A peer-reviewed review article discussing NNMT biology and summarising evidence behind compounds including 5-Amino-1MQ in metabolic research. https://onlinelibrary.wiley.com/doi/10.1155/2021/9924314
• Development and validation of LC-MS/MS assay for 5-Amino-1-methyl quinolinium
  Important analytical reference confirming laboratory assahttps://onlinelibrary.wiley.com/doi/10.1155/2021/9924314y development and compound detection for research use. https://pubmed.ncbi.nlm.nih.gov/34304009/