Humanin – 10mg Research Compound

Humanin – Research Compound

Humanin is a naturally occurring peptide produced inside the mitochondria, the energy-producing powerhouses of cells. Often referred to in longevity science as a protective signalling molecule, it plays a key role in defending cells against premature damage. In laboratory settings, it is investigated primarily for how it supports cellular survival, energy production, and natural defence mechanisms under physical and metabolic stress.

Findings from early-stage clinical trials have reported:

• Enhanced cellular survival and protection against premature cell death in stress models.
• Reductions in oxidative stress and markers of cellular wear and tear.
• Support for healthy blood vessel function and cardiovascular tissue resilience.
• Improvements in markers associated with metabolic health and cellular energy maintenance.

Researchers study Humanin to explore the biological pathways involved in healthy ageing, cellular defence, and brain health, with particular interest in its potential relevance to longevity and shielding vital tissues from age-related decline.

Available Formats:
This compound is available as a vial of lyophilised powder, or can be ordered in a disposable pen, a reusable pen, or a cartridge for an existing reusable pen system.

Used solely for in vitro experiments and cannot be:

• Used in clinical trials involving humans
• Administered to humans as part of an experiment or investigation
• Supplied to another party for human investigational use

References

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
This study investigated Humanin in human retinal pigment epithelial cells and found protective effects against oxidative stress-induced cell death, reduced reactive oxygen species formation, and restoration of mitochondrial bioenergetics under experimental stress conditions.
Source Link: Available here

Humanin: A Novel Central Regulator of Peripheral Insulin Action
This preclinical study examined Humanin and related analogues in metabolic research and reported effects on insulin sensitivity, glucose regulation, and signalling pathways involved in metabolic homeostasis.
Source Link: Available here

Humanin Directly Protects Cardiac Mitochondria Against Dysfunction Initiated by Oxidative Stress by Decreasing Complex I Activity
This experimental study investigated the effects of a Humanin analogue on cardiac mitochondria exposed to oxidative stress and reported protective effects on mitochondrial function, supporting further research into Humanin’s cardiovascular and cellular stress-response pathways.
Source Link: Available here

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review
This systematic review summarises research on Humanin in ageing, oxidative stress, mitochondrial function, cardiovascular biology, metabolic regulation, and neuroprotective pathways, highlighting its broader role as a mitochondrial-derived signalling peptide.
Source Link: Available here